Single-cell RNA sequencing to decipher the immunogenicity of ChAdOx1 nCoV-19/AZD1222 and mRNA-1273 vaccines in patients with autoimmune rheumatic diseases

Single-cell RNA sequencing to decipher the immunogenicity of ChAdOx1 nCoV-19/AZD1222 and mRNA-1273 vaccines in patients with autoimmune rheumatic diseases

ObjectivesTo investigate the differences between the vector vaccine ChAdOx1 nCoV-19/AZD1222 (Oxford-AstraZeneca) and mRNA-based vaccine mRNA-1273 (Moderna) in patients with autoimmune rheumatic diseases (AIRD), and to explore the cell-cell interactions between high and low anti-SARS-CoV-2 IgG levels...

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Bibliographic Details
Main Authors: Yen-Ju Chen, Po-Liang Cheng, Wen-Nan Huang, Hsin-Hua Chen, Hong-Wei Chen, Jun-Peng Chen, Ching-Tsai Lin, Kuo-Tung Tang, Wei-Ting Hung, Tsu-Yi Hsieh, Yi-Hsing Chen, Yi-Ming Chen, Tzu-Hung Hsiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
COVID-19 vaccine
rheumatic disease
autoimmune
anti-rheumatic medications
single-cell RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.920865/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.920865/full

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