Advantage of a Narrow Spectrum Host Defense (Antimicrobial) Peptide Over a Broad Spectrum Analog in Preclinical Drug Development

Advantage of a Narrow Spectrum Host Defense (Antimicrobial) Peptide Over a Broad Spectrum Analog in Preclinical Drug Development

The APO-type proline-arginine-rich host defense peptides exhibit potent in vitro killing parameters against Enterobacteriaceae but not to other bacteria. Because of the excellent in vivo properties against systemic and local infections, attempts are regularly made to further improve the activity spe...

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Bibliographic Details
Main Authors: Eszter Ostorhazi, Ralf Hoffmann, Nicole Herth, John D. Wade, Carl N. Kraus, Laszlo Otvos Jr.
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Chemistry
Subjects:
Acinetobacter baumannii
anti-inflammatory cytokines
ARV-1502
bacteremia model
minimal inhibitory concentration
toxicity
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00359/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2018.00359/full

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