Mettl3-m6A-Creb1 forms an intrinsic regulatory axis in maintaining iNKT cell pool and functional differentiation

Mettl3-m6A-Creb1 forms an intrinsic regulatory axis in maintaining iNKT cell pool and functional differentiation

Summary: N6-methyladenosine (m6A) methyltransferase Mettl3 is involved in conventional T cell immunity; however, its role in innate immune cells remains largely unknown. Here, we show that Mettl3 intrinsically regulates invariant natural killer T (iNKT) cell development and function in an m6A-depend...

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Bibliographic Details
Main Authors: Menghao You, Jingjing Liu, Jie Li, Ce Ji, Haochen Ni, Wenhui Guo, Jiarui Zhang, Weiwei Jia, Zhao Wang, Yajiao Zhang, Yingpeng Yao, Guotao Yu, Huanyu Ji, Xiaohu Wang, Dali Han, Xuguang Du, Meng Michelle Xu, Shuyang Yu
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723005958

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http://www.sciencedirect.com/science/article/pii/S2211124723005958

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