The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies

The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies

Signal transducer and activator of transcription 3 (STAT3), a member of the STAT protein family, can be phosphorylated by receptor-associated Janus kinases (JAKs) in response to stimulation by cytokines and growth factors. It forms homo- or heterodimers that can translocate to the cell nucleus where...

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Bibliographic Details
Main Authors: Loukik Arora, Alan Prem Kumar, Frank Arfuso, Wee Joo Chng, Gautam Sethi
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cancers
Subjects:
STAT3
hematological malignancies
targeted inhibition
proliferation
anti-apoptosis
Online Access:http://www.mdpi.com/2072-6694/10/9/327

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http://www.mdpi.com/2072-6694/10/9/327

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