The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies
Signal transducer and activator of transcription 3 (STAT3), a member of the STAT protein family, can be phosphorylated by receptor-associated Janus kinases (JAKs) in response to stimulation by cytokines and growth factors. It forms homo- or heterodimers that can translocate to the cell nucleus where...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-09-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/10/9/327 |
| _version_ | 1797763542128001024 |
|---|---|
| author | Loukik Arora Alan Prem Kumar Frank Arfuso Wee Joo Chng Gautam Sethi |
| author_facet | Loukik Arora Alan Prem Kumar Frank Arfuso Wee Joo Chng Gautam Sethi |
| author_sort | Loukik Arora |
| collection | DOAJ |
| description | Signal transducer and activator of transcription 3 (STAT3), a member of the STAT protein family, can be phosphorylated by receptor-associated Janus kinases (JAKs) in response to stimulation by cytokines and growth factors. It forms homo- or heterodimers that can translocate to the cell nucleus where they act as transcription activators. Constitutive activation of STAT3 has been found to be associated with initiation and progression of various cancers. It can exert proliferative as well as anti-apoptotic effects. This review focuses on the role of STAT3 in pathogenesis i.e., proliferation, differentiation, migration, and apoptosis of hematological malignancies viz. leukemia, lymphoma and myeloma, and briefly highlights the potential therapeutic approaches developed against STAT3 activation pathway. |
| first_indexed | 2024-03-12T19:42:57Z |
| format | Article |
| id | doaj.art-1735119774bd4ae7973b74f6cd4a1ba2 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T19:42:57Z |
| publishDate | 2018-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-1735119774bd4ae7973b74f6cd4a1ba22023-08-02T03:41:44ZengMDPI AGCancers2072-66942018-09-0110932710.3390/cancers10090327cancers10090327The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological MalignanciesLoukik Arora0Alan Prem Kumar1Frank Arfuso2Wee Joo Chng3Gautam Sethi4Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeStem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6102, AustraliaCancer Science Institute of Singapore, Centre for Translational Medicine, 14 Medical Drive, #11-01M, Singapore 117599, SingaporeDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeSignal transducer and activator of transcription 3 (STAT3), a member of the STAT protein family, can be phosphorylated by receptor-associated Janus kinases (JAKs) in response to stimulation by cytokines and growth factors. It forms homo- or heterodimers that can translocate to the cell nucleus where they act as transcription activators. Constitutive activation of STAT3 has been found to be associated with initiation and progression of various cancers. It can exert proliferative as well as anti-apoptotic effects. This review focuses on the role of STAT3 in pathogenesis i.e., proliferation, differentiation, migration, and apoptosis of hematological malignancies viz. leukemia, lymphoma and myeloma, and briefly highlights the potential therapeutic approaches developed against STAT3 activation pathway.http://www.mdpi.com/2072-6694/10/9/327STAT3hematological malignanciestargeted inhibitionproliferationanti-apoptosis |
| spellingShingle | Loukik Arora Alan Prem Kumar Frank Arfuso Wee Joo Chng Gautam Sethi The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies Cancers STAT3 hematological malignancies targeted inhibition proliferation anti-apoptosis |
| title | The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies |
| title_full | The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies |
| title_fullStr | The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies |
| title_full_unstemmed | The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies |
| title_short | The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies |
| title_sort | role of signal transducer and activator of transcription 3 stat3 and its targeted inhibition in hematological malignancies |
| topic | STAT3 hematological malignancies targeted inhibition proliferation anti-apoptosis |
| url | http://www.mdpi.com/2072-6694/10/9/327 |
| work_keys_str_mv | AT loukikarora theroleofsignaltransducerandactivatoroftranscription3stat3anditstargetedinhibitioninhematologicalmalignancies AT alanpremkumar theroleofsignaltransducerandactivatoroftranscription3stat3anditstargetedinhibitioninhematologicalmalignancies AT frankarfuso theroleofsignaltransducerandactivatoroftranscription3stat3anditstargetedinhibitioninhematologicalmalignancies AT weejoochng theroleofsignaltransducerandactivatoroftranscription3stat3anditstargetedinhibitioninhematologicalmalignancies AT gautamsethi theroleofsignaltransducerandactivatoroftranscription3stat3anditstargetedinhibitioninhematologicalmalignancies AT loukikarora roleofsignaltransducerandactivatoroftranscription3stat3anditstargetedinhibitioninhematologicalmalignancies AT alanpremkumar roleofsignaltransducerandactivatoroftranscription3stat3anditstargetedinhibitioninhematologicalmalignancies AT frankarfuso roleofsignaltransducerandactivatoroftranscription3stat3anditstargetedinhibitioninhematologicalmalignancies AT weejoochng roleofsignaltransducerandactivatoroftranscription3stat3anditstargetedinhibitioninhematologicalmalignancies AT gautamsethi roleofsignaltransducerandactivatoroftranscription3stat3anditstargetedinhibitioninhematologicalmalignancies |