PDPN marks a subset of aggressive and radiation-resistant glioblastoma cells

PDPN marks a subset of aggressive and radiation-resistant glioblastoma cells

Treatment-resistant glioma stem cells are thought to propagate and drive growth of malignant gliomas, but their markers and our ability to target them specifically are not well understood. We demonstrate that podoplanin (PDPN) expression is an independent prognostic marker in gliomas across multiple...

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Bibliographic Details
Main Authors: Aram S. Modrek, Eskil Eskilsson, Ravesanker Ezhilarasan, Qianghu Wang, Lindsey D. Goodman, Yingwen Ding, Ze-Yan Zhang, Krishna P. L. Bhat, Thanh-Thuy T. Le, Floris P. Barthel, Ming Tang, Jie Yang, Lihong Long, Joy Gumin, Frederick F. Lang, Roel G. W. Verhaak, Kenneth D. Aldape, Erik P. Sulman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
glioma
glioblastoma
PDPN
podoplanin
CD133
radioresistance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.941657/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.941657/full

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