Synthetic Lethal Targeting of Mitotic Checkpoints in HPV-Negative Head and Neck Cancer

Synthetic Lethal Targeting of Mitotic Checkpoints in HPV-Negative Head and Neck Cancer

Head and neck squamous cell carcinomas (HNSCC) affect more than 800,000 people annually worldwide, causing over 15,000 deaths in the US. Among HNSCC cancers, human papillomavirus (HPV)-negative HNSCC has the worst outcome, motivating efforts to improve therapy for this disease. The most common mutat...

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Bibliographic Details
Main Authors: Alexander Y. Deneka, Margret B. Einarson, John Bennett, Anna S. Nikonova, Mohamed Elmekawy, Yan Zhou, Jong Woo Lee, Barbara A. Burtness, Erica A. Golemis
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
prexasertib
adavosertib
mitotic catastrophe
head and neck cancer
Online Access:https://www.mdpi.com/2072-6694/12/2/306

Internet

https://www.mdpi.com/2072-6694/12/2/306

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