FGF15 promotes hepatic NPC1L1 degradation in lithogenic diet-fed mice

FGF15 promotes hepatic NPC1L1 degradation in lithogenic diet-fed mice

Abstract Background Cholesterol gallstone disease (CGD) is accompanied by biliary cholesterol supersaturation. Hepatic Niemann-Pick C1-like 1 (NPC1L1), which is present in humans but not in wild-type (WT) mice, promotes hepatocyte cholesterol uptake and decreases biliary cholesterol supersaturation....

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Bibliographic Details
Main Authors: Pingfan Mo, Hongtan Chen, Xin Jiang, Fengling Hu, Fenming Zhang, Guodong Shan, Wenguo Chen, Sha Li, Yiqiao Li, Guoqiang Xu
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Lipids in Health and Disease
Subjects:
Cholesterol gallstone disease
NPC1L1
Ezetimibe
Ubiquitination
FGF15
Online Access:https://doi.org/10.1186/s12944-022-01709-8

Internet

https://doi.org/10.1186/s12944-022-01709-8

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