In Vivo HIV-1 Cell-to-Cell Transmission Promotes Multicopy Micro-compartmentalized Infection

HIV-1 infection is enhanced by adhesive structures that form between infected and uninfected T cells called virological synapses (VSs). This mode of transmission results in the frequent co-transmission of multiple copies of HIV-1 across the VS, which can reduce sensitivity to antiretroviral drugs. S...

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Hlavní autoři: Kenneth M. Law, Natalia L. Komarova, Alice W. Yewdall, Rebecca K. Lee, Olga L. Herrera, Dominik Wodarz, Benjamin K. Chen
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2016-06-01
Edice:Cell Reports
On-line přístup:http://www.sciencedirect.com/science/article/pii/S221112471630657X