The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression

The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression

Tumor cell-microenvironment interactions generate heterogeneity and promote progression. Here, Ma et al. show that the E3 ligase SIAH2 degrades NRF1 in response to hypoxia to enhance pro-tumor metabolic and environmental effects, whereas NRF1 stabilization sensitizes tumor cells to apoptosis.

Bibliographic Details
Main Authors: Biao Ma, Hongcheng Cheng, Chenglong Mu, Guangfeng Geng, Tian Zhao, Qian Luo, Kaili Ma, Rui Chang, Qiangqiang Liu, Ruize Gao, Junli Nie, Jiaying Xie, Jinxue Han, Linbo Chen, Gui Ma, Yushan Zhu, Quan Chen
Format: Article
Language:English
Published: Nature Portfolio 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08618-y

Internet

https://doi.org/10.1038/s41467-019-08618-y

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