FJU-C4, a new 2-pyridone compound, attenuates lipopolysaccharide-induced systemic inflammation via p38MAPK and NF-κB in mice.

FJU-C4, a new 2-pyridone compound, attenuates lipopolysaccharide-induced systemic inflammation via p38MAPK and NF-κB in mice.

Despite advances in antibiotic therapy and intensive care, the mortality caused by systemic inflammatory response syndrome and severe sepsis remains high. The use of anti-inflammatory agents to attenuate inflammatory response during acute systemic inflammatory reactions may improve survival rates. H...

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Bibliographic Details
Main Authors: Jung-Sen Liu, Fang Jung, Shih-Hsing Yang, Shang-Shing P Chou, Jhih-Liang Huang, Chang-Lin Lu, Guan-Lin Huang, Pan-Chyr Yang, Jau-Chen Lin, Guey-Mei Jow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3871526?pdf=render

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http://europepmc.org/articles/PMC3871526?pdf=render

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