VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling Pathway
Spiral ganglion neurons (SGNs) are important for hearing, and their peripheral and central processes connect sensory cells of the Corti organ to the central nervous system. The resulting network forms a point-to-point auditory conduction. As a cardiac hormone, brain natriuretic peptide (BNP) binds t...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/23/3746 |
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| author | Xinyu Zhang Ke Zhou Keyong Tian Qingwen Zhu Wei Liu Zhenzhen Liu Xiaogang An Chaoyong Tian Yao Li Fei Lu Fei Sun Dingjun Zha |
| author_facet | Xinyu Zhang Ke Zhou Keyong Tian Qingwen Zhu Wei Liu Zhenzhen Liu Xiaogang An Chaoyong Tian Yao Li Fei Lu Fei Sun Dingjun Zha |
| author_sort | Xinyu Zhang |
| collection | DOAJ |
| description | Spiral ganglion neurons (SGNs) are important for hearing, and their peripheral and central processes connect sensory cells of the Corti organ to the central nervous system. The resulting network forms a point-to-point auditory conduction. As a cardiac hormone, brain natriuretic peptide (BNP) binds to natriuretic peptide receptor type A leading to diuresis, vasodilatation, inhibition of renin and aldosterone production, and cardiac and vascular myocyte growth. This study primarily aimed to explore the expression and function of BNP in the rat’s inner ear and elucidate its regulatory mechanism. We determined the expression and function of BNP and found that the vitamin D receptor (VDR) could upregulate the expression of BNP and enhance its function. In SGNs of the rat inner ear, BNP promotes neuron survival and prolongs neurite length through the cGMP-PKG signaling pathway, which could be regulated by VDR and provide a novel approach for neuronal regeneration therapy. To the best of our knowledge, this is the first study to report this potential transcriptional regulatory relationship and will act as a reference for research on neuronal regeneration therapy for SGNs injury. |
| first_indexed | 2024-03-09T17:51:04Z |
| format | Article |
| id | doaj.art-17431cf0cebd4016a6008565bbbafc2c |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T17:51:04Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-17431cf0cebd4016a6008565bbbafc2c2023-11-24T10:43:06ZengMDPI AGCells2073-44092022-11-011123374610.3390/cells11233746VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling PathwayXinyu Zhang0Ke Zhou1Keyong Tian2Qingwen Zhu3Wei Liu4Zhenzhen Liu5Xiaogang An6Chaoyong Tian7Yao Li8Fei Lu9Fei Sun10Dingjun Zha11Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi’an 710032, ChinaDepartment of Laboratory Medicine, Institute of Clinical Laboratory Medicine of PLA, Xijing Hospital, Air Force Military Medical University, Xi’an 710032, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi’an 710032, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi’an 710032, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi’an 710032, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi’an 710032, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi’an 710032, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi’an 710032, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi’an 710032, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi’an 710032, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi’an 710032, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi’an 710032, ChinaSpiral ganglion neurons (SGNs) are important for hearing, and their peripheral and central processes connect sensory cells of the Corti organ to the central nervous system. The resulting network forms a point-to-point auditory conduction. As a cardiac hormone, brain natriuretic peptide (BNP) binds to natriuretic peptide receptor type A leading to diuresis, vasodilatation, inhibition of renin and aldosterone production, and cardiac and vascular myocyte growth. This study primarily aimed to explore the expression and function of BNP in the rat’s inner ear and elucidate its regulatory mechanism. We determined the expression and function of BNP and found that the vitamin D receptor (VDR) could upregulate the expression of BNP and enhance its function. In SGNs of the rat inner ear, BNP promotes neuron survival and prolongs neurite length through the cGMP-PKG signaling pathway, which could be regulated by VDR and provide a novel approach for neuronal regeneration therapy. To the best of our knowledge, this is the first study to report this potential transcriptional regulatory relationship and will act as a reference for research on neuronal regeneration therapy for SGNs injury.https://www.mdpi.com/2073-4409/11/23/3746sensorineural hearing lossvitamin D receptorbrain natriuretic peptidespiral ganglion neuronsneuronal regeneration therapy |
| spellingShingle | Xinyu Zhang Ke Zhou Keyong Tian Qingwen Zhu Wei Liu Zhenzhen Liu Xiaogang An Chaoyong Tian Yao Li Fei Lu Fei Sun Dingjun Zha VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling Pathway Cells sensorineural hearing loss vitamin D receptor brain natriuretic peptide spiral ganglion neurons neuronal regeneration therapy |
| title | VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling Pathway |
| title_full | VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling Pathway |
| title_fullStr | VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling Pathway |
| title_full_unstemmed | VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling Pathway |
| title_short | VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling Pathway |
| title_sort | vdr regulates bnp promoting neurite growth and survival of cochlear spiral ganglion neurons through cgmp pkg signaling pathway |
| topic | sensorineural hearing loss vitamin D receptor brain natriuretic peptide spiral ganglion neurons neuronal regeneration therapy |
| url | https://www.mdpi.com/2073-4409/11/23/3746 |
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