Early ciliary and prominin-1 dysfunctions precede neurogenesis impairment in a mouse model of type 2 diabetes

Early ciliary and prominin-1 dysfunctions precede neurogenesis impairment in a mouse model of type 2 diabetes

Diabetes mellitus (DM) is reaching epidemic conditions worldwide and increases the risk for cognition impairment and dementia. Here, we postulated that progenitors in adult neurogenic niches might be particularly vulnerable. Therefore, we evaluated the different components of the mouse subventricula...

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Bibliographic Details
Main Authors: Tomás P. Bachor, Jana Karbanová, Edgar Büttner, Vicente Bermúdez, Melisa Marquioni-Ramella, Peter Carmeliet, Denis Corbeil, Angela M. Suburo
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Neurobiology of Disease
Subjects:
CD133
Cilia
Diabetes
Glucose transporter
Neurogenesis
Prominin, Subventricular zone
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117301638

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http://www.sciencedirect.com/science/article/pii/S0969996117301638

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