Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids

Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids

Abstract Understanding the mechanisms involved in colonic epithelial differentiation is key to unraveling the alterations causing inflammatory conditions and cancer. Organoid cultures provide an unique tool to address these questions but studies are scarce. We report a differentiation system toward...

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Bibliographic Details
Main Authors: Pilar Bustamante-Madrid, Antonio Barbáchano, David Albandea-Rodríguez, Javier Rodríguez-Cobos, Nuria Rodríguez-Salas, Isabel Prieto, Aurora Burgos, Jaime Martínez de Villarreal, Francisco X. Real, José Manuel González-Sancho, María Jesús Larriba, Miguel Lafarga, Alberto Muñoz, Asunción Fernández-Barral
Format: Article
Language:English
Published: Nature Publishing Group 2024-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06680-z

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https://doi.org/10.1038/s41419-024-06680-z

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