Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins

Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins

Complexin is a critical presynaptic protein that regulates both spontaneous and calcium-triggered neurotransmitter release in all synapses. Although the SNARE-binding central helix of complexin is highly conserved and required for all known complexin functions, the remainder of the protein has profo...

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Bibliographic Details
Main Authors: Rachel T. Wragg, Daniel A. Parisotto, Zhenlong Li, Mayu S. Terakawa, David Snead, Ishani Basu, Harel Weinstein, David Eliezer, Jeremy S. Dittman
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
complexin
membrane binding
synaptic transmission
synaptic vesicles
molecular dynamics
evolutionary conservation and diversification
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00146/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00146/full

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