Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells

Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells

Accumulation of reactive oxygen species (i.e., oxidative stress) is a leading cause of beta cell dysfunction and apoptosis in diabetes. NRF2 (NF-E2 p45-related factor-2) regulates the adaptation to oxidative stress, and its activity is negatively regulated by the redox-sensitive CUL3 (cullin-3) ubiq...

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Bibliographic Details
Main Authors: Chinmai Patibandla, Lidy van Aalten, Albena T. Dinkova-Kostova, Tadashi Honda, Antonio Cuadrado, Raquel Fernández-Ginés, Alison D. McNeilly, John D. Hayes, James Cantley, Calum Sutherland
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Redox Biology
Subjects:
NRF2
GSK3
β-TrCP
β cells
Islets
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724000934

Internet

http://www.sciencedirect.com/science/article/pii/S2213231724000934

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