Impairments of Synaptic Plasticity Induction Threshold and Network Oscillatory Activity in the Hippocampus Underlie Memory Deficits in a Non-Transgenic Mouse Model of Amyloidosis

Impairments of Synaptic Plasticity Induction Threshold and Network Oscillatory Activity in the Hippocampus Underlie Memory Deficits in a Non-Transgenic Mouse Model of Amyloidosis

In early Alzheimer disease (AD) models synaptic failures and upstreaming aberrant patterns of network synchronous activity result in hippocampal-dependent memory deficits. In such initial stage, soluble forms of Amyloid-<i>β</i> (A<i>β</i>) peptides have been shown to play a...

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Bibliographic Details
Main Authors: Jennifer Mayordomo-Cava, Guillermo Iborra-Lázaro, Souhail Djebari, Sara Temprano-Carazo, Irene Sánchez-Rodríguez, Danko Jeremic, Agnès Gruart, José María Delgado-García, Lydia Jiménez-Díaz, Juan D. Navarro-López
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Biology
Subjects:
Alzheimer model
amyloid-<i>β</i>
hippocampus
in vivo
synaptic plasticity
metaplasticity
Online Access:https://www.mdpi.com/2079-7737/9/7/175

Internet

https://www.mdpi.com/2079-7737/9/7/175

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