Development of HIV-Resistant CAR T Cells by CRISPR/Cas-Mediated CAR Integration into the <i>CCR5</i> Locus

Development of HIV-Resistant CAR T Cells by CRISPR/Cas-Mediated CAR Integration into the <i>CCR5</i> Locus

Adoptive immunotherapy using chimeric antigen receptor (CAR) T cells has been highly successful in treating B cell malignancies and holds great potential as a curative strategy for HIV infection. Recent advances in the use of anti-HIV broadly neutralizing antibodies (bNAbs) have provided vital infor...

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Bibliographic Details
Main Authors: Frederik Holm Rothemejer, Nanna Pi Lauritsen, Anna Karina Juhl, Mariane Høgsbjerg Schleimann, Saskia König, Ole Schmeltz Søgaard, Rasmus O. Bak, Martin Tolstrup
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Viruses
Subjects:
HIV
CAR T cells
CRISPR/Cas9
humanized mice
Online Access:https://www.mdpi.com/1999-4915/15/1/202

Internet

https://www.mdpi.com/1999-4915/15/1/202

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