Downregulation of Renal Hsa-miR-127-3p Contributes to the Overactivation of Type I Interferon Signaling Pathway in the Kidney of Lupus Nephritis

Downregulation of Renal Hsa-miR-127-3p Contributes to the Overactivation of Type I Interferon Signaling Pathway in the Kidney of Lupus Nephritis

MicroRNAs are involved in the pathogenesis of systemic lupus erythematosus (SLE) and dysregulated in the kidneys of lupus nephritis (LN) patients, but their pathogenic roles in LN are largely unknown. Janus Kinase 1 (JAK1) mediates the activation of the downstream signaling pathways of many inflamma...

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Bibliographic Details
Main Authors: Lingling Wu, Xiao Han, Xiaoyue Jiang, Huihua Ding, Chaojun Qi, Zhihua Yin, Jianwei Xiao, Le Xiong, Qiang Guo, Zhizhong Ye, Bo Qu, Nan Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
microRNA
hsa-miR-127-3p
type I interferon
Janus Kinase 1
systemic lupus erythematosus
lupus nephritis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.747616/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.747616/full

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