Targeting HMGB1-NFκb Axis and miR-21 by Glycyrrhizin: Role in Amelioration of Corneal Injury in a Mouse Model of Alkali Burn

Targeting HMGB1-NFκb Axis and miR-21 by Glycyrrhizin: Role in Amelioration of Corneal Injury in a Mouse Model of Alkali Burn

Corneal neovascularization (CNV) is a sight-threatening condition usually associated with various inflammatory settings including chemical injury. High mobility group box 1 (HMGB1) is identified as an inflammatory alarmin in diverse tissue damage. Here, we evaluate the expression of HMGB1 and the co...

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Bibliographic Details
Main Authors: Peihong Wang, Peng Hao, Xi Chen, Linghan Li, Yongying Zhou, Xiaohan Zhang, Lin Zhu, Ming Ying, Ruifang Han, Liming Wang, Xuan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
HMGB1
glycyrrhizin
corneal inflammation
neovascularization
MicroRNA-21
corneal opacity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.841267/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.841267/full

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