De novo analysis of bulk RNA-seq data at spatially resolved single-cell resolution

De novo analysis of bulk RNA-seq data at spatially resolved single-cell resolution

Current methods to reanalyze bulk RNA-seq at spatially resolved single-cell resolution have limitations. Here, the authors develop Bulk2Space, a spatial deconvolution algorithm using single-cell and spatial transcriptomics as references, providing new insights into spatial heterogeneity within bulk...

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Bibliographic Details
Main Authors: Jie Liao, Jingyang Qian, Yin Fang, Zhuo Chen, Xiang Zhuang, Ningyu Zhang, Xin Shao, Yining Hu, Penghui Yang, Junyun Cheng, Yang Hu, Lingqi Yu, Haihong Yang, Jinlu Zhang, Xiaoyan Lu, Li Shao, Dan Wu, Yue Gao, Huajun Chen, Xiaohui Fan
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34271-z

Internet

https://doi.org/10.1038/s41467-022-34271-z

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