De novo analysis of bulk RNA-seq data at spatially resolved single-cell resolution
Current methods to reanalyze bulk RNA-seq at spatially resolved single-cell resolution have limitations. Here, the authors develop Bulk2Space, a spatial deconvolution algorithm using single-cell and spatial transcriptomics as references, providing new insights into spatial heterogeneity within bulk...
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Bibliographic Details
| Main Authors: |
Jie Liao,
Jingyang Qian,
Yin Fang,
Zhuo Chen,
Xiang Zhuang,
Ningyu Zhang,
Xin Shao,
Yining Hu,
Penghui Yang,
Junyun Cheng,
Yang Hu,
Lingqi Yu,
Haihong Yang,
Jinlu Zhang,
Xiaoyan Lu,
Li Shao,
Dan Wu,
Yue Gao,
Huajun Chen,
Xiaohui Fan |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-34271-z
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