The Vitamin E Analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM)

The Vitamin E Analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM)

Statins; a class of routinely prescribed cholesterol-lowering drugs; inhibit 3-hydroxy-3-methylglutaryl-coenzymeA reductase (HMGCR) and strongly induce endothelial thrombomodulin (TM); which is known to have anti-inflammatory; anti-coagulation; anti-oxidant; and radioprotective properties. However;...

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Bibliographic Details
Main Authors: Rupak Pathak, Sanchita P. Ghosh, Daohong Zhou, Martin Hauer-Jensen
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:International Journal of Molecular Sciences
Subjects:
gamma-tocotrienol
statins
thrombomodulin
activated protein C
endothelial cells
Kruppel-like transcription factors
Online Access:http://www.mdpi.com/1422-0067/17/11/1937

Internet

http://www.mdpi.com/1422-0067/17/11/1937

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