Sequestration within peptide coacervates improves the fluorescence intensity, kinetics, and limits of detection of dye-based DNA biosensors

Abstract Peptide-based liquid-liquid phase separated domains, or coacervates, are a biomaterial gaining new interest due to their exciting potential in fields ranging from biosensing to drug delivery. In this study, we demonstrate that coacervates provide a simple and biocompatible medium to improve...

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Bibliographic Details
Main Authors: Christopher M. Green, Deborah Sementa, Divita Mathur, Joseph S. Melinger, Priyasha Deshpande, Shana Elbaum-Garfinkle, Igor L. Medintz, Rein V. Ulijn, Sebastián A. Díaz
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-024-01124-3