Human monoclonal antibodies isolated from a primary pneumococcal conjugate Vaccinee demonstrates the expansion of an antigen-driven Hypermutated memory B cell response

Human monoclonal antibodies isolated from a primary pneumococcal conjugate Vaccinee demonstrates the expansion of an antigen-driven Hypermutated memory B cell response

Abstract Background Community-acquired pneumonia is a leading infectious cause of hospitalization. A few vaccines exist to prevent pneumococcal disease in adults, including a pneumococcal polysaccharide unconjugated vaccine and a protein conjugated polysaccharide vaccine. Previous studies on the hum...

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Bibliographic Details
Main Authors: Zhifeng Chen, Kara S. Cox, Aimin Tang, Jeanette Roman, Malorie Fink, Robin M. Kaufhold, Liming Guan, Andy Xie, Melissa A. Boddicker, Debra Mcguinness, Xiao Xiao, Hualin Li, Julie M. Skinner, Thorsten Verch, Mary Retzlaff, Kalpit A. Vora
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Infectious Diseases
Subjects:
Monoclonal antibodies
Human
Plasmablast B cell
Pneumococcal conjugate vaccine
Online Access:http://link.springer.com/article/10.1186/s12879-018-3517-7

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http://link.springer.com/article/10.1186/s12879-018-3517-7

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