Utility of Lymphocyte Transformation Test for Assisting Updated Roussel Uclaf Causality Assessment Method in Drug-Induced Liver Injury: A Case-Control Study

Utility of Lymphocyte Transformation Test for Assisting Updated Roussel Uclaf Causality Assessment Method in Drug-Induced Liver Injury: A Case-Control Study

Background: The Roussel Uclaf Causality Assessment Method (RUCAM) is a validated tool for assessing causality in cases of suspected drug-induced liver injury (DILI). However, RUCAM cannot discriminate between concomitant hepatotoxic drugs with the same temporal sequence.Objective: To analyse the uti...

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Bibliographic Details
Main Authors: Amelia Rodríguez, Irene García-García, Lucía Martínez de Soto, Arturo Gómez López De Las Huertas, Alberto M. Borobia, Andrea González-Torbay, Ibtissam Akatbach-Bousaid, Miguel González-Muñoz, Elena Ramírez
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
drug-induced liver injury (DILI)
clinical pharmacology
pharmacovigilance
updated roussel uclaf causality assessment method (updated RUCAM)
causality assessment
lymphocyte transformation test (LTT)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.819589/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.819589/full

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