Uridine and pyruvate protect T cells’ proliferative capacity from mitochondrial toxic antibiotics: a clinical pilot study

Uridine and pyruvate protect T cells’ proliferative capacity from mitochondrial toxic antibiotics: a clinical pilot study

Abstract Antibiotics that inhibit bacterial protein or nucleic acid synthesis and function can exert an off-target action on mitochondria (mitotoxic antibiotics), making actively dividing mammalian cells dependent on uridine and pyruvate supplementation. Based on this rationale, we carried out, for...

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Bibliographic Details
Main Authors: Stefano Battaglia, Stefania De Santis, Monica Rutigliano, Fabio Sallustio, Angela Picerno, Maria Antonia Frassanito, Ingo Schaefer, Angelo Vacca, Antonio Moschetta, Peter Seibel, Michele Battaglia, Gaetano Villani
Format: Article
Language:English
Published: Nature Portfolio 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-91559-8

Internet

https://doi.org/10.1038/s41598-021-91559-8

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