Combinatorial strategies for production improvement of anti-tuberculosis antibiotics ilamycins E1/E2 from deep sea-derived Streptomyces atratus SCSIO ZH16 ΔilaR

Combinatorial strategies for production improvement of anti-tuberculosis antibiotics ilamycins E1/E2 from deep sea-derived Streptomyces atratus SCSIO ZH16 ΔilaR

Abstract Ilamycins E1/E2 are novel cyclic heptapeptides from Streptomyces atratus SCSIO ZH16, which have the MIC value of 9.8 nM against Mycobacterium tuberculosis H37Rv. However, the lower fermentative titer of ilamycins E1/E2 cut off further development for novel anti-TB lead drugs. In order to br...

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Bibliographic Details
Main Authors: Yunfei Zhu, Gaofan Zheng, Xiujuan Xin, Junying Ma, Jianhua Ju, Faliang An
Format: Article
Language:English
Published: SpringerOpen 2022-10-01
Series:Bioresources and Bioprocessing
Subjects:
Ilamycins
Streptomyces atratus
Fermentation optimization
Exogenous adding strategy
Online Access:https://doi.org/10.1186/s40643-022-00599-z

Internet

https://doi.org/10.1186/s40643-022-00599-z

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