Comparison of pharmacokinetic profiles of seven major bioactive components in normal and non-alcoholic fatty liver disease (NAFLD) rats after oral administration of Ling-Gui-Zhu-Gan decoction by UPLC-MS/MS

Comparison of pharmacokinetic profiles of seven major bioactive components in normal and non-alcoholic fatty liver disease (NAFLD) rats after oral administration of Ling-Gui-Zhu-Gan decoction by UPLC-MS/MS

A sensitive and rapid ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) method was hereby developed for the determination of seven components, namely, glycyrrhizic acid, glycyrrhetinic acid, dehydrotumulosic acid, isoliquiritin, liquiritin, atractylenolide III, and cinnam...

Full description

Bibliographic Details
Main Authors: Wenlong Nie, Yang Yang, Ling Li, Yue Ding, Xingmi Chen, Ming Li, Ning He, Guang Ji, Yong Zhang, Ping Kang, Tong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
NAFLD
UPLC-MS/MS
comparative pharmacokinetics
rat plasma
Ling-Gui-Zhu-Gan decoction
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1174742/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1174742/full

Similar Items