The three-dimensionality of the hiPSC-CM spheroid contributes to the variability of the field potential

The three-dimensionality of the hiPSC-CM spheroid contributes to the variability of the field potential

Background: Field potential (FP) signals from human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) spheroid which are used for drug safety tests in the preclinical stage are different from action potential (AP) signals and require working knowledge of the multi-electrode array (MEA)...

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Bibliographic Details
Main Authors: Minki Hwang, Su-Jin Lee, Chul-Hyun Lim, Eun Bo Shim, Hyang-Ae Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Physiology
Subjects:
hiPSC-CM
multi-electrode array
field potential
drug toxicity
simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1123190/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1123190/full

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