Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms

Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms

Abstract Background Abnormalities in the 5-HT system and synaptic plasticity are hallmark features of schizophrenia. Previous studies suggest that the human endogenous retrovirus W family envelope (ERVWE1) is an influential risk factor for schizophrenia and inversely correlates with 5-HT4 receptor i...

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Bibliographic Details
Main Authors: Xiulin Wu, Lianzhong Liu, Xing Xue, Xuhang Li, Kexin Zhao, Jiahang Zhang, Wenshi Li, Wei Yao, Shuang Ding, Chen Jia, Fan Zhu
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Cell & Bioscience
Subjects:
Schizophrenia
ERVWE1
HTR1B
ALKBH5
Synaptic plasticity
Online Access:https://doi.org/10.1186/s13578-023-01167-4

Internet

https://doi.org/10.1186/s13578-023-01167-4

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