Broad induction of immunoregulatory mechanisms after a short course of anti-IL-7Rα antibodies in NOD mice

Broad induction of immunoregulatory mechanisms after a short course of anti-IL-7Rα antibodies in NOD mice

Abstract Background Type 1 diabetes is an autoimmune disease caused by T cell-mediated destruction of the insulin-producing β-cells in the pancreas. Therefore, approaches that effectively halt the pathogenic T cell response are predicted to have preventive or therapeutic benefit for type 1 diabetes...

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Bibliographic Details
Main Authors: Cristina Vazquez-Mateo, Justin Collins, Michelle Fleury, Hans Dooms
Format: Article
Language:English
Published: BMC 2017-03-01
Series:BMC Immunology
Subjects:
Type 1 diabetes
Interleukin 7
T cells
Autoimmunity
Tregs
Inhibitory receptors
Online Access:http://link.springer.com/article/10.1186/s12865-017-0201-4

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http://link.springer.com/article/10.1186/s12865-017-0201-4

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