IL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice.

IL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice.

Beige fat dissipates energy and functions as a defense against cold and obesity, but the mechanism for its development is unclear. We found that interleukin (IL)-25 signaling through its cognate receptor, IL-17 receptor B (IL-17RB), increased in adipose tissue after cold exposure and β3-adrenoceptor...

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Bibliographic Details
Main Authors: Lingyi Li, Lei Ma, Zewei Zhao, Shiya Luo, Baoyong Gong, Jin Li, Juan Feng, Hui Zhang, Weiwei Qi, Ti Zhou, Xia Yang, Guoquan Gao, Zhonghan Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-08-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001348

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https://doi.org/10.1371/journal.pbio.3001348

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