Deciphering smooth muscle cell heterogeneity in atherosclerotic plaques and constructing model: a multi-omics approach with focus on KLF15/IGFBP4 axis

Deciphering smooth muscle cell heterogeneity in atherosclerotic plaques and constructing model: a multi-omics approach with focus on KLF15/IGFBP4 axis

Abstract Background Ruptured atherosclerotic plaques often precipitate severe ischemic events, such as stroke and myocardial infarction. Unraveling the intricate molecular mechanisms governing vascular smooth muscle cell (VSMC) behavior in plaque stabilization remains a formidable challenge. Methods...

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Bibliographic Details
Main Authors: Zhanli Peng, Qinghui Kan, Kangjie Wang, Tang Deng, Shenming Wang, Ridong Wu, Chen Yao
Format: Article
Language:English
Published: BMC 2024-05-01
Series:BMC Genomics
Subjects:
Atherosclerosis
Smooth muscle cell
Single-cell
Online Access:https://doi.org/10.1186/s12864-024-10379-y

Internet

https://doi.org/10.1186/s12864-024-10379-y

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