A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis

A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis

Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) is a member of the basic helix-loop-helix/PER-ARNT-SIM (bHLH/PAS) transcription factor family. ARNT2 heterodimerizes with several members of the family, including single-minded homolog-1 (SIM1) and neuronal PAS domain protein 4 (NPAS4), primar...

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Bibliographic Details
Main Authors: Emre E. Turer, Miguel San Miguel, Kuan-wen Wang, William McAlpine, Feiya Ou, Xiaohong Li, Miao Tang, Zhao Zang, Jianhui Wang, Braden Hayse, Bret Evers, Xiaoming Zhan, Jamie Russell, Bruce Beutler
Format: Article
Language:English
Published: The Company of Biologists 2018-12-01
Series:Disease Models & Mechanisms
Subjects:
N-ethyl-N-nitrosourea
ENU
Obesity
Hyperphagia
Online Access:http://dmm.biologists.org/content/11/12/dmm035451

Internet

http://dmm.biologists.org/content/11/12/dmm035451

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