Endogenous IFITMs boost SARS-coronavirus 1 and 2 replication whereas overexpression inhibits infection by relocalizing ACE2

Endogenous IFITMs boost SARS-coronavirus 1 and 2 replication whereas overexpression inhibits infection by relocalizing ACE2

Summary: Opposing effects of interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) on SARS-CoV-2 infection have been reported. The reasons for this are unclear and the role of IFITMs in infection of other human coronaviruses (hCoVs) remains poorly understood. Here, we demonstrate that endoge...

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Bibliographic Details
Main Authors: Qinya Xie, Caterina Prelli Bozzo, Laura Eiben, Sabrina Noettger, Dorota Kmiec, Rayhane Nchioua, Daniela Niemeyer, Meta Volcic, Jung-Hyun Lee, Fabian Zech, Konstantin M.J. Sparrer, Christian Drosten, Frank Kirchhoff
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:iScience
Subjects:
Protein
Immunity
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223004728

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223004728

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