Evaluation of the Binding Mechanism of Human Defensin 5 in a Bacterial Membrane: A Simulation Study

Evaluation of the Binding Mechanism of Human Defensin 5 in a Bacterial Membrane: A Simulation Study

Human α-defensin 5 (HD5) is a host-defense peptide exhibiting broad-spectrum antimicrobial activity. The lipopolysaccharide (LPS) layer on the Gram-negative bacterial membrane acts as a barrier to HD5 insertion. Therefore, the pore formation and binding mechanism remain unclear. Here, the binding me...

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Bibliographic Details
Main Authors: Tadsanee Awang, Phoom Chairatana, Ranjit Vijayan, Prapasiri Pongprayoon
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
antimicrobial peptides
human defensin 5
lipopolysaccharide
molecular dynamics simulations
Online Access:https://www.mdpi.com/1422-0067/22/22/12401

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https://www.mdpi.com/1422-0067/22/22/12401

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