Chimeric anti-staphylococcal enterotoxin B antibodies and lovastatin act synergistically to provide in vivo protection against lethal doses of SEB.

Chimeric anti-staphylococcal enterotoxin B antibodies and lovastatin act synergistically to provide in vivo protection against lethal doses of SEB.

Staphylococcal enterotoxin B (SEB) is one of a family of toxins secreted by Staphylococcus aureus that act as superantigens, activating a large fraction of the T-cell population and inducing production of high levels of inflammatory cytokines that can cause toxic shock syndrome (TSS) and death. Extr...

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Bibliographic Details
Main Authors: Mulualem E Tilahun, Alan Kwan, Kannan Natarajan, Megan Quinn, Ashenafi Y Tilahun, Chen Xie, David H Margulies, Barbara A Osborne, Richard A Goldsby, Govindarajan Rajagopalan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3216929?pdf=render

Internet

http://europepmc.org/articles/PMC3216929?pdf=render

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