Increased Resection at DSBs in G<sub>2</sub>-Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ

Increased Resection at DSBs in G<sub>2</sub>-Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ

The load of DNA double-strand breaks (DSBs) induced in the genome of higher eukaryotes by different doses of ionizing radiation (IR) is a key determinant of DSB repair pathway choice, with homologous recombination (HR) and ATR substantially gaining ground at doses below 0.5 Gy. Increased resection a...

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Bibliographic Details
Main Authors: Huaping Xiao, Fanghua Li, Emil Mladenov, Aashish Soni, Veronika Mladenova, Bing Pan, Rositsa Dueva, Martin Stuschke, Beate Timmermann, George Iliakis
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
DSB repair
DNA-PKcs
c-NHEJ
DNA end-resection
ionizing radiation
Online Access:https://www.mdpi.com/2073-4409/11/13/2099

Internet

https://www.mdpi.com/2073-4409/11/13/2099

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