Increased Resection at DSBs in G<sub>2</sub>-Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ
The load of DNA double-strand breaks (DSBs) induced in the genome of higher eukaryotes by different doses of ionizing radiation (IR) is a key determinant of DSB repair pathway choice, with homologous recombination (HR) and ATR substantially gaining ground at doses below 0.5 Gy. Increased resection a...
Główni autorzy: | , , , , , , , , , |
---|---|
Format: | Artykuł |
Język: | English |
Wydane: |
MDPI AG
2022-07-01
|
Seria: | Cells |
Hasła przedmiotowe: | |
Dostęp online: | https://www.mdpi.com/2073-4409/11/13/2099 |