Visible‐Light‐Activated Molecular Machines Kill Fungi by Necrosis Following Mitochondrial Dysfunction and Calcium Overload

Visible‐Light‐Activated Molecular Machines Kill Fungi by Necrosis Following Mitochondrial Dysfunction and Calcium Overload

Abstract Invasive fungal infections are a growing public health threat. As fungi become increasingly resistant to existing drugs, new antifungals are urgently needed. Here, it is reported that 405‐nm‐visible‐light‐activated synthetic molecular machines (MMs) eliminate planktonic and biofilm fungal p...

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Bibliographic Details
Main Authors: Ana L. Santos, Jacob L. Beckham, Dongdong Liu, Gang Li, Alexis vanVenrooy, Antonio Oliver, George P. Tegos, James M. Tour
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Advanced Science
Subjects:
antifungal
fungal mitochondrial phospholipids
molecular machines
reduction of infection‐associated mortality and fungal burden
visible light activation
Online Access:https://doi.org/10.1002/advs.202205781

Internet

https://doi.org/10.1002/advs.202205781

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