Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

Summary: It is well established that long-term depression (LTD) can be initiated by either NMDA or mGluR activation. Here we report that sustained activation of GluK2 subunit-containing kainate receptors (KARs) leads to α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) endocytosi...

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Bibliographic Details
Main Authors: Jithin D. Nair, Ellen Braksator, Busra P. Yucel, Alexandra Fletcher-Jones, Richard Seager, Jack R. Mellor, Zafar I. Bashir, Kevin A. Wilkinson, Jeremy M. Henley
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:iScience
Subjects:
molecular neuroscience
cellular neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221009974

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http://www.sciencedirect.com/science/article/pii/S2589004221009974

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