Three serendipitous pathways in E. coli can bypass a block in pyridoxal‐5′‐phosphate synthesis

Bacterial genomes encode hundreds to thousands of enzymes, most of which are specialized for particular functions. However, most enzymes have inefficient promiscuous activities, as well, that generally serve no purpose. Promiscuous reactions can be patched together to form multistep metabolic pathwa...

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Bibliographic Details
Main Authors: Juhan Kim, Jamie P Kershner, Yehor Novikov, Richard K Shoemaker, Shelley D Copley
Format: Article
Language:English
Published: Springer Nature 2010-01-01
Series:Molecular Systems Biology
Subjects:
Online Access:https://doi.org/10.1038/msb.2010.88