SARS-CoV-2 and ORF3a: Nonsynonymous Mutations, Functional Domains, and Viral Pathogenesis

SARS-CoV-2 and ORF3a: Nonsynonymous Mutations, Functional Domains, and Viral Pathogenesis

ABSTRACT The effect of the rapid accumulation of nonsynonymous mutations on the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not yet known. The 3a protein is unique to SARS-CoV and is essential for disease pathogenesis. Our study aimed at determining the nonsynonym...

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Bibliographic Details
Main Authors: Elio Issa, Georgi Merhi, Balig Panossian, Tamara Salloum, Sima Tokajian
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mSystems
Subjects:
3a protein
COVID-19
nonsynonymous mutations
ORF3a
SARS-CoV-2
Online Access:https://journals.asm.org/doi/10.1128/mSystems.00266-20

Internet

https://journals.asm.org/doi/10.1128/mSystems.00266-20

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