Residues R1075, D1090, R1095, and C1130 Are Critical in ADAMTS13 TSP8-Spacer Interaction Predicted by Molecular Dynamics Simulation

Residues R1075, D1090, R1095, and C1130 Are Critical in ADAMTS13 TSP8-Spacer Interaction Predicted by Molecular Dynamics Simulation

ADAMTS13 (A Disintegrin and Metalloprotease with Thrombospondin type 1 repeats, member 13) cleaves von Willebrand Factor (VWF) multimers to limit the prothrombotic function of VWF. The deficiency of ADAMTS13 causes a lethal thrombotic microvascular disease, thrombotic thrombocytopenic purpura (TTP)....

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Bibliographic Details
Main Authors: Zhiwei Wu, Junxian Yang, Xubin Xie, Guangjian Liu, Ying Fang, Jianhua Wu, Jiangguo Lin
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
ADAMTS13
VWF
thrombotic thrombocytopenic purpura
auto-inhibition
molecular dynamics simulation
Online Access:https://www.mdpi.com/1420-3049/26/24/7525

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https://www.mdpi.com/1420-3049/26/24/7525

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