ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells

ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer and the chemotherapies such as gemcitabine/nab-paclitaxel are confronted with intrinsic or acquired resistance. The aim of this study was to investigate mechanisms underlying paclitaxel resistance in...

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Bibliographic Details
Main Authors: Cecilia Bergonzini, Alessandro Gregori, Tessa M. S. Hagens, Vera E. van der Noord, Bob van de Water, Annelien J. M. Zweemer, Bircan Coban, Mjriam Capula, Giulia Mantini, Asia Botto, Francesco Finamore, Ingrid Garajova, Liam A. McDonnell, Thomas Schmidt, Elisa Giovannetti, Erik H. J. Danen
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pancreatic cancer
Paclitaxel resistance
ABCB1
Kinase-inhibitors
Online Access:https://doi.org/10.1186/s13046-023-02879-8

Internet

https://doi.org/10.1186/s13046-023-02879-8

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