Genotoxic stress induces Sca‐1‐expressing metastatic mammary cancer cells

Genotoxic stress induces Sca‐1‐expressing metastatic mammary cancer cells

We describe a cell damage‐induced phenotype in mammary carcinoma cells involving acquisition of enhanced migratory and metastatic properties. Induction of this state by radiation required increased activity of the Ptgs2 gene product cyclooxygenase 2 (Cox2), secretion of its bioactive lipid product p...

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Bibliographic Details
Main Authors: Jianlin Gong, Benjamin J. Lang, Desheng Weng, Takanori Eguchi, Ayesha Murshid, Thiago J. Borges, Sachin Doshi, Baizheng Song, Mary A. Stevenson, Stuart K. Calderwood
Format: Article
Language:English
Published: Wiley 2018-08-01
Series:Molecular Oncology
Subjects:
genotoxic stress
radiation bystander effect
radiation therapy
responses to cancer therapy
Sca‐1
Online Access:https://doi.org/10.1002/1878-0261.12321

Internet

https://doi.org/10.1002/1878-0261.12321

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