The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy

The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy

Calcium (Ca2+) dysregulation is a hallmark of heart failure and is characterized by impaired Ca2+ sequestration into the sarcoplasmic reticulum (SR) by the SR-Ca2+-ATPase (SERCA). We recently discovered a micropeptide named DWORF (DWarf Open Reading Frame) that enhances SERCA activity by displacing...

Full description

Bibliographic Details
Main Authors: Catherine A Makarewich, Amir Z Munir, Gabriele G Schiattarella, Svetlana Bezprozvannaya, Olga N Raguimova, Ellen E Cho, Alexander H Vidal, Seth L Robia, Rhonda Bassel-Duby, Eric N Olson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
calcium
contractility
cardiac
heart failure
cardiomyopathy
SERCA
Online Access:https://elifesciences.org/articles/38319

Internet

https://elifesciences.org/articles/38319

Similar Items