Human Norovirus Aptamer Exhibits High Degree of Target Conformation-Dependent Binding Similar to That of Receptors and Discriminates Particle Functionality

Human Norovirus Aptamer Exhibits High Degree of Target Conformation-Dependent Binding Similar to That of Receptors and Discriminates Particle Functionality

ABSTRACT Although two in vitro cultivation methods have been reported, discrimination of infectious human norovirus particles for study of viral inactivation is still a challenge, as both rely on reverse transcriptase quantitative PCR. Histo-blood group antigen (HBGA) binding assays serve as a proxy...

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Bibliographic Details
Main Authors: Matthew D. Moore, Benjamin G. Bobay, Brittany Mertens, Lee-Ann Jaykus
Format: Article
Language:English
Published: American Society for Microbiology 2016-12-01
Series:mSphere
Subjects:
aptamer
GII.4
histo-blood group antigen
infectivity
noroviruses
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00298-16

Internet

https://journals.asm.org/doi/10.1128/mSphere.00298-16

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