Novel Hydroxamic Acids Containing Aryl-Substituted 1,2,4- or 1,3,4-Oxadiazole Backbones and an Investigation of Their Antibiotic Potentiation Activity

Novel Hydroxamic Acids Containing Aryl-Substituted 1,2,4- or 1,3,4-Oxadiazole Backbones and an Investigation of Their Antibiotic Potentiation Activity

UDP-3-<i>O-</i>(<i>R</i>-3-hydroxymyristoyl)-<i>N</i>-acetylglucosamine deacetylase (LpxC) is a zinc amidase that catalyzes the second step of the biosynthesis of lipid A, which is an outer membrane essential structural component of Gram-negative bacteria. Inhibit...

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Bibliographic Details
Main Authors: Anastasia A. Zhukovets, Vladimir V. Chernyshov, Aidar Z. Al’mukhametov, Tatiana A. Seregina, Svetlana V. Revtovich, Mariia A. Kasatkina, Yulia E. Isakova, Vitalia V. Kulikova, Elena A. Morozova, Anastasia I. Cherkasova, Timur A. Mannanov, Anastasia A. Anashkina, Pavel N. Solyev, Vladimir A. Mitkevich, Roman A. Ivanov
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
hydroxamic acids
1,2,4-oxadiazoles
1,3,4-oxadiazoles
antibacterial compounds
antibiotic potentiation
gram-negative bacteria
Online Access:https://www.mdpi.com/1422-0067/25/1/96

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https://www.mdpi.com/1422-0067/25/1/96

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