The endoplasmic reticulum stress sensor IRE1α modulates macrophage metabolic function during Brucella abortus infection

The endoplasmic reticulum stress sensor IRE1α modulates macrophage metabolic function during Brucella abortus infection

Endoplasmic reticulum (ER) stress plays a major role in several inflammatory disorders. ER stress induces the unfolded protein response (UPR), a conserved response broadly associated with innate immunity and cell metabolic function in various scenarios. Brucella abortus, an intracellular pathogen, t...

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Bibliographic Details
Main Authors: Erika S. Guimarães, Marco Túlio R. Gomes, Rodrigo C. O. Sanches, Kely Catarine Matteucci, Fábio V. Marinho, Sergio C. Oliveira
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
UPR
endoplasmic reticulum stress
IRE1α
immunometabolism
HIF-1α
brucella abortus
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1063221/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1063221/full

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